Detailed view for PF3D7_1123100

Basic information

TDR Targets ID: 1711
Plasmodium falciparum, calcium-dependent protein kinase 7
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.7928 | Length (AA): 2265 | MW (Da): 265136 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain
PF00169   PH domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0005524   ATP binding  
GO:0005509   calcium ion binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 41 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
25 158 1s6c (A) 48 204 34.00 0.00000047 1 0.44 -0.6
1678 2103 2acx (A) 46 496 22.00 0 1 0.42 -0.12
1757 2265 1omw (A) 103 653 18.00 0 1 0.03 0.36
1810 2078 1yrp (A) 2 276 40.00 0 1 0.73 -1.65
1815 2127 2bdw (A) 6 315 33.00 0 1 0.37 -1.28
465 608 2ap3 (A) 47 192 29.00 0.54 0.01 0.381076 -1.78
782 1122 4dvz (A) 410 798 23.00 0.039 0.88 0.249052 -0.22
796 954 4tql (A) 14 192 28.00 0.62 0.38 0.323699 -1.27
1676 2108 4tnd (A) 44 484 22.00 0 1 0.33267 0.44
1710 1813 2yry (A) 18 120 26.00 0.0000048 1 0.327416 0.14
1766 2132 3uto (A) 98 465 26.00 0.00000012 1 0.299931 -0.04
1767 2130 4lqq (D) 302 707 28.00 0 0.89 0.128206 1.57
1786 2119 4wih (A) 8 336 28.00 0.00000024 1 0.322361 -0.41
1801 2199 4rgj (A) 45 466 29.00 0.00000023 1 0.321059 -0.11
1802 2034 2ofv (A) 236 457 33.00 0.00000014 1 0.18037 0.61
1814 2183 3mwu (A) 0 433 38.00 0 1 0.513855 -0.22
1815 2079 4czu (A) 25 288 39.00 0.0000024 1 0.457898 -0.57
1815 2141 4rgj (A) 63 391 41.00 0 1 0.503871 -0.31
1817 2100 3c0g (B) 8 299 34.00 0.00000003 1 0.431286 -0.82
1817 2079 1phk (A) 15 289 41.00 0.0000015 1 0.428015 -0.58
1823 2020 3ppz (A) 553 751 34.00 0.0000000067 1 0.436917 -0.41
1823 2020 3dtc (A) 146 349 38.00 0.000000012 1 0.287917 0.28
5 128 4by5 (A) 23 128 37.00 0.038 0.73 0.192831 0.42
25 212 2ehb (A) 30 199 29.00 0.25 1 0.213441 0.17
65 123 1jfj (A) 2 60 19.00 0.065 0.23 0.185775 0.29
69 127 2b1u (A) 87 145 20.00 0.76 0.67 0.285775 -0.17
463 612 2ap3 (A) 47 192 30.00 0.79 0.06 0.350454 -1.71
800 958 4tql (A) 14 192 28.00 0.66 0.38 0.322477 -1.27
1648 2080 4tnd (A) 44 484 22.00 0 1 0.334963 0.44
1672 2104 3pfq (A) 185 655 23.00 0.0000088 1 0.153663 1.24
1682 1785 2yry (A) 18 120 26.00 0.0000043 1 0.327891 0.14
1739 2102 4lqq (D) 302 707 28.00 0 0.93 0.137118 1.54
1758 2091 4wih (A) 8 336 28.00 0.00000021 1 0.324407 -0.41
1773 2171 4rgj (A) 45 466 29.00 0.00000017 1 0.323464 -0.11
1774 1993 3vo3 (A) 814 1107 32.00 0.00055 1 0.290746 -0.06
1780 2111 3hx4 (A) 38 366 37.00 0.0000000039 1 0.406513 -0.14
1785 2100 3nie (A) 22 417 30.00 0.001 1 0.177361 -0.42
1787 2113 4rgj (A) 63 391 41.00 0 1 0.503578 -0.31
1789 2072 3c0g (B) 8 299 34.00 0.000000027 1 0.433056 -0.82
1789 2051 1phk (A) 15 289 41.00 0.0000011 1 0.429668 -0.58
1795 1992 3dtc (A) 146 349 38.00 0.000000014 1 0.286911 0.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile merozoite, Oocyst, Sporozoite, Female Gametocyte, Male Gametocyte. PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, sporozoite, early ring, late ring, late schizont, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 48 hs, gametocyte, early schizont, early trophozoite, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_131887)

Species Accession Gene Product
Arabidopsis thaliana AT5G10930   CBL-interacting protein kinase 5
Arabidopsis thaliana AT5G07070   CBL-interacting protein kinase 2
Arabidopsis thaliana AT5G58380   CBL-interacting serine/threonine-protein kinase 10
Arabidopsis thaliana AT5G25110   CBL-interacting serine/threonine-protein kinase 25
Babesia bovis BBOV_II000610   asparagine rich protein, putative
Echinococcus granulosus EgrG_001009400   Kv channel interacting protein 4
Echinococcus multilocularis EmuJ_001009400   Kv channel interacting protein 4
Neospora caninum NCLIV_044860   hypothetical protein
Oryza sativa 4332786   Os03g0339900
Oryza sativa 4338445   Os05g0332300
Oryza sativa 4344287   Os07g0678600
Plasmodium berghei PBANKA_0925200   calcium-dependent protein kinase 7
Plasmodium falciparum PF3D7_1123100   calcium-dependent protein kinase 7
Plasmodium knowlesi PKNH_0920900   calcium-dependent protein kinase 7, putative
Plasmodium vivax PVX_091770   calcium-dependent protein kinase 7, putative
Plasmodium yoelii PY00029   myosin light chain kinase
Toxoplasma gondii TGME49_228750   calcium dependent protein kinase CDPK7
Theileria parva TP04_0518   protein kinase, putative

Essentiality

PF3D7_1123100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0925200 Plasmodium berghei Essential plasmo
TGME49_228750 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 29.6% 291 aa Compounds References
Rattus norvegicus Mitogen-activated protein kinase 1 358 aa 29.8% 289 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 25.8% 287 aa Compounds References
Patiria pectinifera Cdc2 300 aa 29.6% 294 aa Compounds References
Rattus norvegicus Cell division protein kinase 5 292 aa 26.7% 285 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 34.2% 158 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 30.0% 287 aa Compounds References
Rattus norvegicus MAP kinase p38 alpha 360 aa 25.7% 307 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0039 0.5 0.5
0.0059 1 1
0.0064 0.3377 0
0.0018 0.5 0.5
0.0063 1 1
0.0022 0.5 0.5
0.0063 0.7244 0.7244
0.0062 0.6935 0
0.0081 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0011 1 0.5
0.0012 0.5 0.5
0.0098 0.3242 0.2614
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0007 0.5 0.5
0.0033 1 1
0.0061 0.6883 1
0.0027 1 0.5
0.0016 0.5 0.5
0.0003 0.5 0.5
0.0023 0.5 0.5
0.0056 1 0.5
0.0037 1 0.5
0.0029 0.5 0.5
0.0036 0.5 0.5
0.0092 1 0.5
0.0081 1 0.5
0.0012 0.5 0.5
0.0007 0.5 0.5
0.0059 1 1
0.0059 1 1
0.0039 0.5 0.5
0.0033 0.5 0.5
0.0091 1 0.5
0.0026 0.5 0.5
0.0066 0.3101 0
0.0088 0.4477 0.5
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0069 0.3067 1
0.0039 0.9485 0.5
0.0067 0.5 0.5
0.0093 0.8828 0
0.0042 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1123100 (Plasmodium falciparum), calcium-dependent protein kinase 7
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